Osteogenesis

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Hello,

Can you make osteogenesis faster with stem cells? Do you know doctors that use this practise?

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Sure, what my initial question was intended to know whether stem cells could improve the consolidation phase. Ration of 1 cm with externals is 2 months, but this article suggests improvement to 23 days with bone marrow-derived stem cell, which is from my nonmedical point of view is quite easy to apply in practice.


"Staged leg lengthening allows achondroplastic dwarfs to reach nearly normal height, but it takes long periods of external fixation and it can be burdened by delayed unions. Between 2009 and 2013, eight achondroplastic dwarfs showed delayed unions in the callus formation during femoral lengthening stages in our institute. We performed in-situ injections of bone marrow-derived stem cell concentrates. Patients underwent monthly clinical and radiographic assessment for determination of the healing rate. All eight patients showed an improvement in the regenerated bone, with an average healing index of 23.1 days/cm (range: 18.7-23.8 days/cm). The complete recovery of the delayed consolidation took on an average of 5.2 months (range: 2-10 months). The use of cellular therapy in these patients could represent an innovative application."
https://pubmed.ncbi.nlm.nih.gov/30444751/

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Quote from: SkyHigh77 on November 08, 2020, 11:06:45 PMwait do you want your bone to heal faster while LL? I'm a bit confused about what you're asking. ofc stem cells would help with osteogenesis but I am not sure why you would want to risk speeding up bone while LL

By osteogenesis, I was referring to new bone growth and formation. Could you please explain in more detail why it is risky to use stem cells to reduce the consolidation time?

My goal is to find alternatives for invasive procedures such as LATN which may cause tendonitis of the patellar ligament. Maybe LATP would be an alternative if stem cells are too risky?

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Quote from: InStrydeMyFaith on November 08, 2020, 11:15:26 PMIf you mean accelerating consolidation after finishing lengthening, I think several doctors offer this option, at least for those who have bad consolidation

For sure I know that Donghoon does

Thanks! Im actually looking into Dr. Solomin