Quote from: YungGud on September 11, 2020, 11:28:39 AMohh,i would love to get taller without CLL,even in 2022
Yes, if we manage to reopen growth plates growing taller for adults should be easy. Now there are many growth-promoting substances that are safer than HGH. Indirubin-3′-oxime is one of them.
I quote from this source about indirubin-3′-oxime: https://www.researchgate.net/publication/335759824_Indirubin-3'-oxime_stimulates_chondrocyte_maturation_and_longitudinal_bone_growth_via_activation_of_the_Wntb-catenin_pathway
“Longitudinal growth of bones is driven by the proliferation and differentiation of cartilage cells in the growth plate. Choi and colleagues screened a chemical library and identified a compound derived from traditional Chinese herbs, which efficiently promotes this bone growth process in cultured cartilage cells and in the tibias of three-week-old mice. This compound appears safe, suggesting a potentially better avenue for promoting height growth.”
Quote from: Antoine on September 11, 2020, 11:35:20 AMI read it some time ago. I don’t know much about it, I know that fullerenes can be toxic, but trying C60 olive oil shouldn’t be so dangerous. However I’m a little bit skeptical about results, I doubt it can really increase height.
Yeah, I don't know tbh.
Quote from: Antoine on September 11, 2020, 11:45:06 AMYes, if we manage to reopen growth plates growing taller for adults should be easy. Now there are many growth-promoting substances that are safer than HGH. Indirubin-3′-oxime is one of them.
I quote from this source about indirubin-3′-oxime: https://www.researchgate.net/publication/335759824_Indirubin-3'-oxime_stimulates_chondrocyte_maturation_and_longitudinal_bone_growth_via_activation_of_the_Wntb-catenin_pathway
“Longitudinal growth of bones is driven by the proliferation and differentiation of cartilage cells in the growth plate. Choi and colleagues screened a chemical library and identified a compound derived from traditional Chinese herbs, which efficiently promotes this bone growth process in cultured cartilage cells and in the tibias of three-week-old mice. This compound appears safe, suggesting a potentially better avenue for promoting height growth.”
Interesting.
You've seen this right? (LPP + indirubin) https://www.reddit.com/r/looksmaxxing/comments/hmj34y/what_future_heightmaxxing_regimen_may_look/
Yeah, I took a look at that. It seems really promising to me, but it is a complex and potentially dangerous drug stack that I wouldn’t test directly on humans. Very interesting, but it needs a lot of testing.
Quote from: Antoine on September 11, 2020, 11:45:06 AMYes, if we manage to reopen growth plates growing taller for adults should be easy. Now there are many growth-promoting substances that are safer than HGH. Indirubin-3′-oxime is one of them.
I quote from this source about indirubin-3′-oxime: https://www.researchgate.net/publication/335759824_Indirubin-3'-oxime_stimulates_chondrocyte_maturation_and_longitudinal_bone_growth_via_activation_of_the_Wntb-catenin_pathway
“Longitudinal growth of bones is driven by the proliferation and differentiation of cartilage cells in the growth plate. Choi and colleagues screened a chemical library and identified a compound derived from traditional Chinese herbs, which efficiently promotes this bone growth process in cultured cartilage cells and in the tibias of three-week-old mice. This compound appears safe, suggesting a potentially better avenue for promoting height growth.”
I really hope that they find alternatives that are much faster than this surgery! but the thing is growth plates are no longer existent in my age of 21 for example , so what would they open? 
it transforms from cartilage to solid bone once it closes and in my case that was very early due to hormone or endocrine imbalance !!
Quote from: Kenda on September 11, 2020, 01:30:56 PM
I really hope that they find alternatives that are much faster than this surgery! but the thing is growth plates are no longer existent in my age of 21 for example , so what would they open?
it transforms from cartilage to solid bone once it closes and in my case that was very early due to hormone or endocrine imbalance !!
This is a really good question and I’m sorry I don’t have a precise answer. However, if this European project succeeds in reactivating damaged growth plates in children, I guess it wouldn’t be so difficult to reactivate them also in adults, because the bone bar in children with damaged growth plates is similar to the barrier in the adults’ long bones and also because adults too seem to have stem cells that maybe could reactivate growth plates https://www.nature.com/articles/d41586-019-00527-w
Seems too good to be true in reality for at least another 10 years tbh, likely way more
Quote from: levsfri on September 11, 2020, 05:30:20 PMSeems too good to be true in reality for at least another 10 years tbh, likely way more
Maybe you’re right, maybe not. I think that if we join the forces and fund research, good results would come out not long from now.
Quote from: levsfri on September 11, 2020, 05:30:20 PMSeems too good to be true in reality for at least another 10 years tbh, likely way more
And you are very optimistic.
Quote from: Body Builder on September 11, 2020, 07:07:12 PMAnd you are very optimistic.
Optimism and pessimism are relative concepts in a world where it doesn’t take much to revolutionize a field in a positive (iPhone?) or negative (COVID-19?) way.
However, it’s a fact that Oviedo University is leading a research to regenerate injured growth plate in children. This project will be completed in 2022. If they manage to regenerate damaged growth plates in children, it is likely that the same technique or a similar technique works for adults. These are all facts. It could happen or not, they could succeed or not. But it’s not impossibile, we might have a solution within 2022.
Honestly both sides are correct. We may very well see growth plate regenerative technology in the coming years. However, the timeline of when that will be available to the general market will probably be long, in the order of decades.
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