What is the future of limb lengthening? What do you hope to see happen?

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Quote from: Michael J. Assayag, MD on September 13, 2020, 04:30:55 PM
Quite the contrary, I’d love to see better, easier technology. I just question the feasibility behind it. Nature is still better than us... But I would love to be proven wrong on that topic.

Honestly this isn’t about me, or any surgeon for that matter. I’d be very content with the simple treatment of joint replacement, ACL reconstruction, and fracture treatment That would be an awesome life

So did you look at the patent that was showed to you: https://www.freepatentsonline.com/y2020/0223824.html?

First you said it's impossible.

Then you said it will hit the market in the future.

As for LSJL, you can read this: http://www.naturalheightgrowth.com/2020/08/29/new-lsjl-paper-update-revising-lsjl-method/

And we also have this: https://www.reddit.com/r/looksmaxxing/comments/hmj34y/what_future_heightmaxxing_regimen_may_look/

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Yep. I would personally hate it if my LLS profession got 'replaced' by this (or any other technology)
Quote from: Bruce Wayne on September 13, 2020, 04:35:03 PMAnd we also have this: https://www.reddit.com/r/looksmaxxing/comments/hmj34y/what_future_heightmaxxing_regimen_may_look/

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For the record, Dr. Dror Paley was incredibly ignorant when asked about other possible methods and he would lie about the safety and consequences of LL.

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Quote from: Drop-Loud on September 13, 2020, 01:08:19 PMHi Antoine,

Some peeptide manufacturers I think will be able to produce it, but I'm 100% sure they wont sell it to private individuals. In general, they work with pharmaceutical and biotechnology companies, colleges, universities, medical research institutions....

Maybe some manufacturers in India or China would sell to private individuals, but is it safe? That's a big question.

Hi Drop-Loud. I agree with you, that’s the big question. I’m not sure if this site sells peptides to individuals or not. We should investigate.
https://www.antibodies-online.com/peptide/938765/LPP+peptide/


The Korean compound seems promising to me. I guess it will be really useful for people with open growth plates. As for adults with fused growth plates, who knows? We could give it a try.
This is an example of the study behind the compound. It is written by the inventors and gives interesting information.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458850/

A complete overview of the compound patent can be found here.
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2018194309

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Quote from: Michael J. Assayag, MD on September 13, 2020, 02:04:33 PMWell, the problem is feasibility of reopening growth plates. It sounds good on paper.

However closed growth plates are virtually indistinguishable from regular bone. Reopening growth plates is for now, an impossibility. I’d be highly surprised to see such a technology in the future. We do use for some medical conditions, medications that delay growth plate closures.

https://grantome.com/grant/NIH/R21-AR061265-02
In this project Ballock and Alsberg, an orthopedic surgeon and a professor respectively, stated that if we find a way to restore injured growth plates in children, then we could be able to regenerate growth plates in adults: “Successful regeneration of growth plate cartilage architecture in vivo would have a transformational impact on the practice of pediatric orthopaedic surgery, providing for the first time not only the ability to replace growth plates irreversibly damaged by trauma, infection or irradiation, but also the possibility of restoring longitudinal growth in individuals beyond the age of skeletal maturity.”
It was just an hypothesis, of course. Do you think that this hypothesis is far-fetched?

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Quote from: Bruce Wayne on September 13, 2020, 05:16:52 PMFor the record, Dr. Dror Paley was incredibly ignorant when asked about other possible methods and he would lie about the safety and consequences of LL.

Got any links/video?

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Quote from: Antoine on September 13, 2020, 05:35:27 PMThis is an example of the study behind the compound. It is written by the inventors and gives interesting information.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458850/

So this is its tl;dr?

"A functionally improved indirubin derivative, KY19382, elongated tibial length through delayed senescence and further activation of the growth plate in adolescent mice. Collectively, our findings reveal an important role for CXXC5 as a suppressor of longitudinal bone growth involving growth plate activity."

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Hi Antoine,

Thanks for sharing these links. We need to find a way to contact this Korean company to have more info about their drug.

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What even is the point of these compounds? We already fkin know how to elongate the growth plate. It's called human growth hormone. The only thing we give a shiet about is reopening growth plate. None of this shiet will do that, they are just an equivalent to hgh. They might even be better than hgh but again, WE DONT CARE, that's not the problem with gaining height as an adult with FUSED PLATES.

UNTIL We find something that opens growth plates again, all this shiet is borderline useless. We are not kids with growth plates, we are adults with ossified ephyphiseal lines already. It's goddamn bone...

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Great information here about growth plates : https://www.tapatalk.com/groups/lsjl/reopening-growth-plates-a-summary-t1033.html#p8141

Other links :
https://www.tapatalk.com/groups/lsjl/doctors-trip-t898.html

https://www.childrenscolorado.org/research-innovation/research-area/orthopedics-orthopedic-surgery/growth-plate-generation/

https://regenexx.com/blog/skeletal-stem-cells-found-living-in-the-growth-plates-may-one-day-make-us-taller/#gref