What is the future of limb lengthening? What do you hope to see happen?

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Another great post about growth plates

https://www.tapatalk.com/groups/lsjl/the-most-important-topic-in-growth-plate-reopening-t1029.html

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Nanobots to perform distraction osteogenesis are decades away at best; Unfortunately, wishful thinking.

Quote from: Drop-Loud on September 20, 2020, 11:12:17 PMHi O_99,

Good Idea to ask him about fullerene (c60). Maybe he will have more scientific info about it. I think we could give it a try as it is safe and easy to find.

Hey, yes.
He's still confident about the LPP thing (in theory), inject it locally (knee) because there is so little that can enter cartilage after you become an adult.
We need test results though.

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Quote from: Body Builder on September 20, 2020, 08:11:39 AMFor sure we can't trust people who believe in miracles and magic pills to get taller compared to veterans who did what they have to to get taller.

I am starting to think that you are mentally unstable because you are really frustrated about your height (we had almost the same height so I truly understand you) but at the same time you are too scared to do LL and you keep believing bs hoping that one day you'll get taller by a miracle or a pill or an injection or something easy like that.
In reality, you'll stay in misery for your whole life because there won't be an alternative until you get so old to not even care about height but to just stay alive.

Wake up dude, LL nowadays is safer than ever. Its a pity to be in a so messed up situation due to being in a height that you hate, without doing something real about that.
I hope one day you'll understand before its too late.

Quote from: extremis on May 27, 2018, 06:42:46 AMLook mate, if you have some problem with me then just insult me straight up instead of being passive-aggressive about it and indirectly alluding to me using idiotic beat-around-the-bush terminology like this. It's laughable to call someone a coward when you do this.

I honestly don't give a sh*t about Stryde. Is it an improvement to the distraction osteogenesis technique? Sure. But it doesn't solve my (and many other people's) problems with distraction osteogenesis, which is the permanent loss of athletic ability and the risk of permanent complications. Both those problems still exist and you stand a very real chance of facing them whether you go to Dr. Paley or "Sarin the butcher" as you like to call him.

It's not a matter of pain or death. I'm not the least bit afraid of either. If these were the only "risks" implicated in CLL, I would be first in line to get it done. I need my athletic ability and cannot afford to have it hampered, which is why CLL is not an acceptable proposition for me. Plenty of others are in the same boat. Still others are not okay with risking ending up like one of the several posters (such as unicorn) whose lives were ruined by distraction osteogenesis.

Despite the fact that I regularly speak about attraction and its ramifications on this board, I'm not interested in getting taller so I can attract women. I'm not interested in sxx or relationships and haven't been for a long time. Getting taller is purely about overcoming my PHYSICAL (and to a lesser extent, social and workplace) limitations, not about peacking.

You look like a luddite imbecile when you spout garbage about "miracles" and "fairy tales" regarding novel technologies. If you don't understand the science, why criticize it? Especially when the relevant technology ALREADY EXISTS (induced Pluripotent Stem Cells) and the principal part of the procedure (generation and implantation of artificial epiphyseal cartilage) has ALREADY BEEN DONE and successfully shown to work in animal models.

If your problems with your height were purely about attracting women then sure, CLL can fix it for you. Get it done and move on. Back to your squat rack to cope with your bullsh*t weights.

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Quote from: Bruce Wayne on September 21, 2020, 01:01:03 PM

A weirdo who didn't know why he even wanted to become taller and had absolutely no will to get taller.
I am sure he still moans and looks for magic pills like you while living in misery.

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Quote from: Body Builder on September 21, 2020, 02:16:38 PMA weirdo who didn't know why he even wanted to become taller and had absolutely no will to get taller.

"..But I'm a creep, I'm a weirdo.
 What the hell I'm doing here?
 I don't belong here.."

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Quote from: O_99 on September 19, 2020, 09:24:17 AMFrom another interesting* post link from him he shared (new): **

*Possibly useful information; links might already have been posted.

** (new one): https://www.reddit.com/r/Peptides/comments/iyjn9o/a_general_list_of_peptides_plus_peptides_you/


1. -Self-improvement;Antarctic krill peptides (AKP) 
https://www.eurekaselect.com/182760/article (but on young mice; 3wks/old)

->AKPs significantly increased the longitudinal bone growth and improved bone strength. In addition, AKPs remarkably promoted proliferation and hypertrophy of chondrocytes in the growth plate.


2. -Self-improvement;ASB20123
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386482/ (on 8wks/old rats; rats stop growing at 7-8mnths/old)
https://pubmed.ncbi.nlm.nih.gov/31509532/ (12 mnths/old rats; not sure why it says with a little epiphyseal plate)

->It potently stimulated skeletal growth in rats in a dose-dependent manner, and sc infusion was more effective than bolus injection at the same dose.


3. 8-Nitro-cGMP promotes bone growth through expansion of growth plate cartilage
https://www.sciencedirect.com/science/article/abs/pii/S0891584917305956?via%3Dihub


4. A newly discovered stem cell that keeps bones growing
https://www.nature.com/articles/d41586-019-00527-w?utm_source=fbk_nnc&utm_medium=social&utm_campaign=naturenews&sf209700336=1


5. -Cosmetic, Healing;NHGFVVEVTNHGFVVEVT 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457080/ (bone renegeration; not sure about this one)
is one of the few selected as osteogenic-enhancing peptides with both the ability for osteogenic cell-selective proliferation and osteogenic differentiation. These results indicate that osteogenic-enhancing peptides are derived from BMP sequences according to the original peptide array method developed in the present study.


6. -Hormonal;PTH
https://link.springer.com/article/10.1007/s007740200011 (Human PTH (1–34) induces longitudinal bone growth in rats; relatively old)

->A stimulatory role for PTH 1-34 on tendon-to-bone healing was first suggested by Rodeo et al. who reported increased bone and fibrocartilage formation after recombinant parathyroid hormone (rhPTH) treatment in a rat rotator cuff model. Additionally, we found that there was a significant increase in the mineralization of the subchondral bone, as determined by alizarin complexone labeling, in the I-PTH group.


7. -Self-improvement;Link protein N-terminal peptide (LPP or Link N)
https://www.sciencedirect.com/science/article/abs/pii/S0003986100917582
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831317/ (1)
https://febs.onlinelibrary.wiley.com/doi/full/10.1111/j.1432-1033.1993.tb17636.x (old) (2)

->Stimulated the proliferation of Cartilage Stem/Progenitor Cells (CSPC) and accelerated the site-directional migration. Higher expression of SOX9, collagen II, and aggrecan were demonstrated in CSPCs treated with LPP. Data suggest that LPP may be a useful therapeutic substitute for direct BMP administration to treat IVD degeneration and to ameliorate IVD-associated chronic low back pain.
It's proposed that this peptide, along with several other compounds, might increase adult height.

(1) Conclusion. LPP showed application prospect in cartilage regeneration medicine by stimulating proliferation, migration, and chondrogenic differentiation of cartilage stem/progenitor cells.

(2) Since a proportion of the link protein extracted from human and pig cartilage has already undergone proteolysis to remove peptides from its N‐terminal region, these peptides may be produced in articular cartilage during the normal process of turnover and ageing.

+Quote from: O_99 on September 19, 2020, 09:24:17 AM-PTD-DBM since this peptide is a CXXC5 inhibitor, it might help with longitudinal bone growth
https://www.life-science-alliance.org/content/lsa/2/2/e201800254.full.pdf

-IGF-2 for longitudinal bone growth
https://pubmed.ncbi.nlm.nih.gov/20499340/
https://pubmed.ncbi.nlm.nih.gov/25910049/

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Hi O_99,

Thank you so much for sharing all this links. It's very promising. Great job!

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Literally only 4 is relevant lol. Fück is this shīt we don't need another form of hgh

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The most interesting finding would be these ones for people who want to grow taller. Maybe some specialists could confirm :


4. A newly discovered stem cell that keeps bones growing
https://www.nature.com/articles/d41586-019-00527-w?utm_source=fbk_nnc&utm_medium=social&utm_campaign=naturenews&sf209700336=1


7. -Self-improvement;Link protein N-terminal peptide (LPP or Link N)
https://www.sciencedirect.com/science/article/abs/pii/S0003986100917582
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831317/ (1)
https://febs.onlinelibrary.wiley.com/doi/full/10.1111/j.1432-1033.1993.tb17636.x (old) (2)

->Stimulated the proliferation of Cartilage Stem/Progenitor Cells (CSPC) and accelerated the site-directional migration. Higher expression of SOX9, collagen II, and aggrecan were demonstrated in CSPCs treated with LPP. Data suggest that LPP may be a useful therapeutic substitute for direct BMP administration to treat IVD degeneration and to ameliorate IVD-associated chronic low back pain.
It's proposed that this peptide, along with several other compounds, might increase adult height.

(1) Conclusion. LPP showed application prospect in cartilage regeneration medicine by stimulating proliferation, migration, and chondrogenic differentiation of cartilage stem/progenitor cells.

(2) Since a proportion of the link protein extracted from human and pig cartilage has already undergone proteolysis to remove peptides from its N‐terminal region, these peptides may be produced in articular cartilage during the normal process of turnover and ageing.


antarctic krill akp seems to work like indirubin if I'm right?

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Quote from: ghkid2019 on September 25, 2020, 10:58:59 PMLiterally only 4 is relevant lol. Fück is this shīt we don't need another form of hgh

For the adults whom had their growth plates closed we need to proliferate not only their existing chondrocytes , but also their dormant chondrocyte stem cells which LPP (Link protein N-terminal peptide) holds a lot of promise to achieve. LPP has been tested on vitro/vivo (https://www.hindawi.com/journals/sci/2018/3217895/
https://onlinelibrary.wiley.com/doi/abs/10.1002/1529-0131(199801)41:1%3C157::AID-ART19%3E3.0.CO;2-J)
and human type II collagen cells (https://onlinelibrary.wiley.com/doi/abs/10.1002/1529-0131(199801)41:1%3C157::AID-ART19%3E3.0.CO;2-J) with positive results.

Quote from: Drop-Loud on September 25, 2020, 10:23:54 PMHi O_99,

Thank you so much for sharing all this links. It's very promising. Great job!

Hey, by the way what's up with this? https://www.tapatalk.com/groups/lsjl/viewtopic.php?p=8384#p8384